中国阿尔茨海默病临床前期主观认知下降诊断流程与规范专家共识下

表3 增加SCD个体处于AD临床前期可能性的特征：SCD叠加（AD临床前期）

1，主观感觉记忆下降而非其他认知功能

2，发病时间<5年

3，起病年龄≥60岁

4，对认知减退存在担忧

5，自我感觉记忆力较同年龄人差

有条件的研究进一步检测：

6，认知下降得到知情者的证实

7，携带载脂蛋白E ε4等位基因（APOE ε4）

8，有AD生物标记物的证据

缩写：AD：阿尔茨海默病；SCD：主观认知下降

  图1   SCD诊断流程图

缩写：MCI: mild cognitive decline, 轻度认知障碍； NC：normalcontrol, 正常对照；SCD：subjectivecognitive decline, 主观认知下降；AD：Alzheimer’ disease, 阿尔茨海默病

执笔陈观群、王晓妮、王培昌

专家委员会成员(按姓氏汉语拼音排序）

蔡彦宁（首都医科大学宣武医院）、陈瑛（首都医科大学宣武医院）、崔碧霄（首都医科大学宣武医院）、杜文莹（首都医科大学宣武医院）、冯凯（北京市顺义区医院）、Frank Jessen（德国科隆大学医院）、高家红（北京大学）、郭起浩（复旦大学附属华山医院）、郝立晓（首都医科大学宣武医院）、韩璎（首都医科大学宣武医院）、贺永（北京师范大学）、胡笑晨（德国科隆大学医院）、李嘉辰（首都医科大学宣武医院）、李轩宇（首都医科大学宣武医院）、卢洁（首都医科大学宣武医院）、门卫伟（北京大学）、穆斌（首都医科大学宣武医院）、孙宇（首都医科大学宣武医院）、王培昌（首都医科大学宣武医院）、王小琪（首都医科大学宣武医院）、汪子琪（首都医科大学宣武医院）、杨柳（首都医科大学宣武医院）、张玲（首都医科大学）、赵维纳（首都医科大学宣武医院）、左西年（中科院心理所）

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